Ahead of Bethesda’s E3 press briefing, Todd Howard took to the Xbox stage to bring fans the first details for Fallout 76. According to Howard, Fallout 76 will take place before any of the other Fallout games and will serve as a mainline entry as opposed to the spin-off fans were expecting.
Source: N4G PC E3: 2018 Fallout 76 To Be the First in the Fallout Timeline