Bethesda has pulled back the curtain on Fallout 76, and some of our assumptions about the game have been proven accurate. It is an online game that involves survival, but if you really want that traditional Fallout experience (or something close to it), that is possible.
While explaining exactly what Fallout 76 is (look out for a full breakdown soon), Todd Howard assured that you can play the game solo if you so desire. You don’t have to team up with other players, and you can avoid the ones you meet online to explore the world on your own.
Fallout 76 is coming this year, and will receive a beta (more soon!) before launch.
Source: Game Informer Fallout 76 Is Entirely Online But Can Be Played Solo