From GameWatcher: “There has been some concern among the Fallout fans about the upcoming offshoot of the core series: Fallout 76. In particular, we know for a fact that there will be no singleplayer as such, and we know that there will be no human NPCs either. Bethesda have explained that Fallout 76 is an experimental experience – something different to keep things fresh. With that, we also know that Fallout 76 is going to be a survival multiplayer game first and foremost, with DNA from the likes of Rust and ARK: Survival Evolved.”
Source: N4G PC Fallout 76: You Can't Get Killed If You're Under Level 5, But You Sure Can Fast Travel