Its honestly difficult to not compare Two Point Hospital with Theme Hospital as the two are almost identical in execution. Sure, there are a few things here and there that are unique to Two Point Hospital such as the art style which kind of expands on the wackiness of the cinematics from Theme Hospital, the illnesses, and the room designs and types. Its instantly familiar but at the same time theres a certain uniqueness to it which keeps the game fresh for both new and old players of this type of game.
Source: N4G PC Two Point Hospital (PC) n3rdabl3 Review