Polygon: “Lets say it simply doesnt work out. The justification may be sound, and the guy giving it may be revered by fans of the Fallout series. But lets say that after Todd Howard, designer of some of the most beloved role-playing games ever, insisted this one have no human NPCs, players just arent digging Fallout 76.”
Source: N4G PC No NPCs in Fallout 76: Its weird, but still workable