From Attack of the Fanboy: “Taking inspiration from such games as Dark Souls and the developers own Darksiders series, Remnant: From the Ashes is not a particularly easy game. Death will come quickly and often throughout your time spent in the Root infested wasteland of this post apocalyptic world. And while changing the difficulty is an option its pretty hidden away and comes with some severe costs. Nevertheless, if youre struggling you will want to know how to change difficulty in Remnant: From the Ashes.”
Source: N4G PC Remnant: From the Ashes – How to Change Difficulty