The tragic events of September 11th 2001 had wide-reaching effects on millions of people, but it was also felt to a far lesser extent in the world of entertainment.
It was already known that the ending of Metal Gear Solid 2, which takes place in New York, was changed following 9/11, but a recently-translated interview with Hideo Kojima reveals how close the game was to being cancelled in the wake of the terrorist attacks
Source: N4G PC 9/11 Almost Caused The Cancellation Of Metal Gear Solid 2 And Kojima's Resignation